Genetics Research

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Genetics Research has developed a new low cost and simple sequence specific enrichment technology platform, called Negative EnrichmentTM. This unique CRISPR/Cas9 approach can enrich for long DNA fragments out of a complex background, and demonstrates significant economic value for NGS analysis.

With applications across research, diagnostics, and therapeutics this proprietary platform can significantly impact the economics and efficiency of sample preparation.

Negative Enrichment
Genomics is integral to biotech. Good sample preparation is critical for genomics in order to avoid garbage-in/garbage-out, and drowning in data. The efficiencies and accuracy of Genetics Research Negative Enrichment™ platform provides an effective approach to sample preparation that yields consistent results focused on the information needed and nothing more.

The Negative Enrichment™ technology is agnostic to the size of targeted sequence of interest. It can be used for rare event detection as represented in cfDNA (e.g. Liquid Biopsy). Design and development of mutation specific or allele specific Cas9/guide RNA complexes followed by our proprietary Negative Enrichment™ approach should enable easier detection of tumor associated mutations in the plasma of cancer patients and result in an increase of clinical informativeness in a recurrence population as well as for early detection. Rare event detection is also common to the area of infectious disease diagnostics. GR's unique approach to enrichment can also address the complexity of NGS based metagenomic pathogen and microbiome diagnostics and can result in accelerating the commercialization of such tests.

Keywords

liquid biopsy, negative enrichment, dna sample preparation

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